Aneuploidy Underlies Rapid Adaptive Evolution of Yeast Cells Deprived of a Conserved Cytokinesis Motor

@article{Rancati2008AneuploidyUR,
  title={Aneuploidy Underlies Rapid Adaptive Evolution of Yeast Cells Deprived of a Conserved Cytokinesis Motor},
  author={Giulia Rancati and Norman Pavelka and Brian E Fleharty and Aaron G. Noll and Rhonda Trimble and Kendra N. Walton and Anoja G. Perera and Karen Staehling-Hampton and Chris W. Seidel and Rong Li},
  journal={Cell},
  year={2008},
  volume={135},
  pages={879-893}
}
The ability to evolve is a fundamental feature of biological systems, but the mechanisms underlying this capacity and the evolutionary dynamics of conserved core processes remain elusive. We show that yeast cells deleted of MYO1, encoding the only myosin II normally required for cytokinesis, rapidly evolved divergent pathways to restore growth and cytokinesis. The evolved cytokinesis phenotypes correlated with specific changes in the transcriptome. Polyploidy and aneuploidy were common genetic… CONTINUE READING
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