Aneuploidies and micronuclei in the germ cells of male mice of advanced age.

@article{Lowe1995AneuploidiesAM,
  title={Aneuploidies and micronuclei in the germ cells of male mice of advanced age.},
  author={Xiu R Lowe and Barbara W. Collins and James W Allen and Nina Titenko-Holland and John Breneman and Marta J Van Beek and Jack B. Bishop and Andrew J. Wyrobek},
  journal={Mutation research},
  year={1995},
  volume={338 1-6},
  pages={59-76}
}
The objective of this research was to determine whether the frequencies of chromosomally defective germ cells increased with age in male laboratory mice. Two types of chromosomal abnormalities were characterized: (1) testicular spermatid aneuploidy (TSA) as measured by a new method of multi-color fluorescence in situ hybridization (FISH) with DNA probes specific for mouse chromosomes X, Y and 8, and (2) spermatid micronucleus (SMN) analyses using anti-kinetochore antibodies. B6C3F1 mice (aged… CONTINUE READING

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