Aneuploid mosaicism in the developing and adult cerebellar cortex.

@article{Westra2008AneuploidMI,
  title={Aneuploid mosaicism in the developing and adult cerebellar cortex.},
  author={Jurjen Westra and Suzanne E. Peterson and Yun C Yung and Tetsuji Mutoh and Serena Barral and Jerold Chun},
  journal={The Journal of comparative neurology},
  year={2008},
  volume={507 6},
  pages={1944-51}
}
Neuroprogenitor cells (NPCs) in several telencephalic proliferative regions of the mammalian brain, including the embryonic cerebral cortex and postnatal subventricular zone (SVZ), display cell division "defects" in normal cells that result in aneuploid adult progeny. Here, we identify the developing cerebellum as a major, nontelencephalic proliferative region of the vertebrate central nervous system (CNS) that also produces aneuploid NPCs and nonmitotic cells. Mitotic NPCs assessed by… CONTINUE READING

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