Aneuploid embryonic stem cells exhibit impaired differentiation and increased neoplastic potential.

@article{Zhang2016AneuploidES,
  title={Aneuploid embryonic stem cells exhibit impaired differentiation and increased neoplastic potential.},
  author={Meili Zhang and Li Cheng and Yuyan Jia and Guang Liu and Cuiping Li and Shuhui Song and Allan Bradley and Yue Huang},
  journal={The EMBO journal},
  year={2016},
  volume={35 21},
  pages={
          2285-2300
        }
}
Aneuploidy leads to severe developmental defects in mammals and is also a hallmark of cancer. However, whether aneuploidy is a driving cause or a consequence of tumor formation remains controversial. Paradoxically, existing studies based on aneuploid yeast and mouse fibroblasts have shown that aneuploidy is usually detrimental to cellular fitness. Here, we examined the effects of aneuploidy on mouse embryonic stem (ES) cells by generating a series of cell lines that each carries an extra copy… CONTINUE READING

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