Aneugenic activity of Op18/stathmin is potentiated by the somatic Q18-->e mutation in leukemic cells.

@article{Holmfeldt2006AneugenicAO,
  title={Aneugenic activity of Op18/stathmin is potentiated by the somatic Q18-->e mutation in leukemic cells.},
  author={Per Holmfeldt and Kristoffer Br{\"a}nnstr{\"o}m and Sonja Stenmark and Martin Gullberg},
  journal={Molecular biology of the cell},
  year={2006},
  volume={17 7},
  pages={
          2921-30
        }
}
Op18/stathmin (Op18) is a phosphorylation-regulated microtubule destabilizer that is frequently overexpressed in tumors. The importance of Op18 in malignancy was recently suggested by identification of a somatic Q18-->E mutation of Op18 in an adenocarcinoma. We addressed the functional consequences of aberrant Op18 expression in leukemias by analyzing the… CONTINUE READING