Anethole, a potential antimicrobial synergist, converts a fungistatic dodecanol to a fungicidal agent

  title={Anethole, a potential antimicrobial synergist, converts a fungistatic dodecanol to a fungicidal agent},
  author={Ken-Ichi Fujita and Tomoko Fujita and Isao Kubo},
  journal={Phytotherapy Research},
Anethole shows synergistic effects on the antifungal activities of phytochemicals including polygodial and (2E)‐undecenal against Saccharomyces cerevisiae and Candida albicans. It was found that a fungistatic dodecanol combined with a sublethal amount of anethole showed a fungicidal activity against S. cerevisiae. The MIC of dodecanol quickly reduced cell viability, but the cell viability recovered shortly after and then finally became no longer different from the control, indicating that the… 
Anethole potentiates dodecanol's fungicidal activity by reducing PDR5 expression in budding yeast.
Results indicated that although anethole reduced the transcription of several transporters, PDR5 expression was particularly relevant to dodecanol efflux, and is expected to be a promising candidate drug for the inhibition of efflux.
Anethole induces apoptotic cell death accompanied by reactive oxygen species production and DNA fragmentation in Aspergillus fumigatus and Saccharomyces cerevisiae
Results suggest that anethole‐induced cell death could be explained by oxidative stress‐dependent apoptosis via typical mitochondrial death cascades in fungi, including A. fumigatus and S. cerevisiae.
Dehydrozingerone Exhibits Synergistic Antifungal Activities in Combination with Dodecanol against Budding Yeast via the Restriction of Multidrug Resistance
Drug resistance in fungal infections has been a more frequent occurrence with the increasing number of immunocompromised patients. In efforts to overcome the problem of fungal drug resistance, we
Organic synthesis and fungicidal activity of oxylipin-based compounds
Previous research has shown that the naturally occurring reactive electrophilic species (RES), 12-oxophytodienoic acid (OPDA), not only serves as a precursor for jasmonic acid but is also a potent
Morphological Changes of the Filamentous Fungus Mucor Mucedo and Inhibition of Chitin Synthase Activity Induced by Anethole
Results suggest that the morphological changes of M. mucedo could be explained by the fragility of cell walls caused by CHS inhibition, and anethole dose‐dependently inhibited chitin synthase (CHS) activity in permeabilized hyphae in an uncompetitive manner.
Antifungal Activity of the Essential Oil of Illicium verum Fruit and Its Main Component trans-Anethole
Both the essential oil and trans-Anethole exhibited strong inhibitory effect against all test fungi indicating that most of the observed antifungal properties was due to the presence of trans-anethole in the oil, which could be developed as natural fungicides for plant disease control in fruit and vegetable preservation.
Evaluation of Antibacterial Activity and Phytochemical Screening of Pimpinella anisem's Essential Oil
Medicinal plants are considered new resources for producing agents that could act as alternatives to antibiotics in treatment of antibiotic-resistant bacteria. The aim of the study was to evaluate
Assessment of Chemical Composition and Antibacterial Effects of Anethole-Rich Hydroalcoholic Extract of Pimpinella anisum
Increasing microbial resistance to chemical antibiotics and their probabilistic side effects cause popularity of medicinal plants, so there is an instantaneous and steady need for novel antimicrobial
Alkylphenol Activity against Candida spp. and Microsporum canis: A Focus on the Antifungal Activity of Thymol, Eugenol and O-Methyl Derivatives
All tested compounds thus showed in vitro antifungal activity against Candida spp.
Essential oil of Chrysanthemum indicum L.: potential biocontrol agent against plant pathogen Phytophthora nicotianae
Phytophthora nicotianae is currently considered one of the most devastating oomycete plant pathogens, and its control frequently relies solely on the use of systemic fungicides. There is an urgent


Potentiation of antifungal activity of sesquiterpene dialdehydes againstCandida albicans and two other fungi
The antifungal activity of two drimane sesquiterpene dialdehydes, polygodial and warburganal, alone and in combination with several other substances, was examined against three fungi employing a broth dilution method.
Potentiation of fungicidal activities of trans-anethole against Saccharomyces cerevisiae under hypoxic conditions.
The fungicidal potency of anethole against a strain capable of respiration under aerobic conditions was enhanced by the addition of a respiratory inhibitor antimycin A3, therefore, anetholes possibly expresses fungicidal activities only against fermentatively growing cells of S. cerevisiae.
Fungicidal activity of polygodial in combination with anethole and indole against Candida albicans
Combining two or more of these chemicals to increase the activity spectrum seems to be a promising approach to practical use, although a rational basis for this is still in an early stage.
Combination effects of antifungal nagilactones against Candida albicans and two other fungi with phenylpropanoids.
Nagilactone E, the most abundant norditerpene dilactone, showed moderate to weak activity against these fungi, but this activity was dramatically enhanced by several naturally occurring phenylpropanoids such as anethole and isosafrole.
Modes of antifungal action of alkanols against Saccharomyces cerevisiae.
The time-kill curve study showed that undecanol was fungicidal against S. cerevisiae at any growth stages, and the maximum activity can be obtained when balance between hydrophilic and hydrophobic portions becomes the most appropriate.
Molecular design of multifunctional food additives: antioxidative antifungal agents.
A series of alkyl 3,4-dihydroxybenzoates (protocatechuates) was synthesized, and their fungicidal activity against Saccharomyces cerevisiae was assayed using a 2-fold serial broth dilution method and the activity was found to correlate with the hydrophobicAlkyl chain length.
Antimicrobial agents from Licaria puchuri-major and their synergistic effect with polygodial.
Unexpectedly, while polygodial did not synergize the antifungal activity of any of the compounds tested, the anti- fungus activity of polygodials was significantly increased when combined with aromatic substances such as anethole, safrole, or methyleugenol.
Inhibitory effects of spices on growth and toxin production of toxigenic fungi
The inhibitory effects of 29 commercial powdered spices on the growth and toxin production of three species of toxigenic Aspergillus were observed by introducing these materials into culture media
Activity and mechanisms of action of selected biocidal agents on Gram-positive and -negative bacteria.
Sub-MIC levels of all ingredients did induce subtle effects on the organisms which impacted bacterial growth, even for those which had no true inhibitory effects.
Antimicrobial agents from Tanacetum balsamita
A series of C 7 -C 11 α,β-unsaturated aldehydes was characterized together with several fatty alcohols and acids as antimicrobial agents from the dried flowers of a Brazilian medicinal plant,