Anethole, a potential antimicrobial synergist, converts a fungistatic dodecanol to a fungicidal agent

@article{Fujita2007AnetholeAP,
  title={Anethole, a potential antimicrobial synergist, converts a fungistatic dodecanol to a fungicidal agent},
  author={Ken-Ichi Fujita and Tomoko Fujita and Isao Kubo},
  journal={Phytotherapy Research},
  year={2007},
  volume={21}
}
Anethole shows synergistic effects on the antifungal activities of phytochemicals including polygodial and (2E)‐undecenal against Saccharomyces cerevisiae and Candida albicans. It was found that a fungistatic dodecanol combined with a sublethal amount of anethole showed a fungicidal activity against S. cerevisiae. The MIC of dodecanol quickly reduced cell viability, but the cell viability recovered shortly after and then finally became no longer different from the control, indicating that the… 
Anethole potentiates dodecanol's fungicidal activity by reducing PDR5 expression in budding yeast.
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Results indicated that although anethole reduced the transcription of several transporters, PDR5 expression was particularly relevant to dodecanol efflux, and is expected to be a promising candidate drug for the inhibition of efflux.
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