Anesthetized- and awake-patched whole-cell recordings in freely moving rats using UV-cured collar-based electrode stabilization

@article{Lee2014AnesthetizedAA,
  title={Anesthetized- and awake-patched whole-cell recordings in freely moving rats using UV-cured collar-based electrode stabilization},
  author={Doyun Lee and Gleb E. Shtengel and Jason E. Osborne and Albert K Lee},
  journal={Nature Protocols},
  year={2014},
  volume={9},
  pages={2784-2795}
}
Intracellular recording allows precise measurement and manipulation of individual neurons, but it requires stable mechanical contact between the electrode and the cell membrane, and thus it has remained challenging to perform in behaving animals. Whole-cell recordings in freely moving animals can be obtained by rigidly fixing ('anchoring') the pipette electrode to the head; however, previous anchoring procedures were slow and often caused substantial pipette movement, resulting in loss of the… CONTINUE READING
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