Anesthetics produce subunit-selective actions on glutamate receptors.

  title={Anesthetics produce subunit-selective actions on glutamate receptors.},
  author={J E Dildy-Mayfield and Edmond I. Eger and R. Adron Harris},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={276 3},
We assessed the involvement of specific glutamate receptors in the action of anesthetics. In addition to the clinical anesthetics enflurane, isoflurane and halothane, we tested novel halogenated compounds, which are anesthetic or nonanesthetic in vivo, on glutamate receptor (GluR) subunits. these volatile compounds as well as pentobarbital and phenobarbital were tested on kainate-induced currents in Xenopus oocytes expressing GluR1, GluR3, GluR2+3 or GluR6 subunits. The anesthetic 1-chloro-1,2… CONTINUE READING

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