Anesthetics alter the physical and functional properties of the Ca-ATPase in cardiac sarcoplasmic reticulum.

@article{Karon1995AnestheticsAT,
  title={Anesthetics alter the physical and functional properties of the Ca-ATPase in cardiac sarcoplasmic reticulum.},
  author={Brad S Karon and Lisa M Geddis and Howard C Kutchai and David D Thomas},
  journal={Biophysical journal},
  year={1995},
  volume={68 3},
  pages={936-45}
}
We have studied the effects of the local anesthetic lidocaine, and the general anesthetic halothane, on the function and oligomeric state of the CA-ATPase in cardiac sarcoplasmic reticulum (SR). Oligomeric changes were detected by time-resolved phosphorescence anisotropy (TPA). Lidocaine inhibited and aggregated the Ca-ATPase in cardiac SR. Micromolar calcium or 0.5 M lithium chloride protected against lidocaine-induced inhibition, indicating that electrostatic interactions are essential to… CONTINUE READING
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