Anesthetic synergy between two n-alkanes.

@article{Brosnan2017AnestheticSB,
  title={Anesthetic synergy between two n-alkanes.},
  author={Robert J Brosnan and Fab{\'i}ola Bono Fukushima and Trung Pham},
  journal={Veterinary anaesthesia and analgesia},
  year={2017},
  volume={44 3},
  pages={
          577-588
        }
}
OBJECTIVE N-butane and n-pentane can both produce general anesthesia. Both compounds potentiate γ-aminobutyric acid type A (GABAA) receptor function, but only butane inhibits N-methyl-d-aspartate (NMDA) receptors. It was hypothesized that butane and pentane would exhibit anesthetic synergy due to their different actions on ligand-gated ion channels. STUDY DESIGN Prospective experimental study. ANIMALS A total of four Xenopus laevis frogs and 43 Sprague-Dawley rats. METHODS Alkane… CONTINUE READING
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