Anesthetic propofol causes glycogen synthase kinase-3β-regulated lysosomal/mitochondrial apoptosis in macrophages.

@article{Hsing2012AnestheticPC,
  title={Anesthetic propofol causes glycogen synthase kinase-3β-regulated lysosomal/mitochondrial apoptosis in macrophages.},
  author={Chung-Hsi Hsing and Yu-hong Chen and Chia-Ling Chen and Wei-Ching Huang and Ming-Chung Lin and Po-Chun Tseng and Chi-Yun Wang and Cheng-Chieh Tsai and Pui-Ching Choi and C G Lin},
  journal={Anesthesiology},
  year={2012},
  volume={116 4},
  pages={868-81}
}
BACKGROUND Overdose propofol treatment with a prolong time causes injury to multiple cell types; however, its molecular mechanisms remain unclear. Activation of glycogen synthase kinase (GSK)-3β is proapoptotic under death stimuli. The authors therefore hypothesize that propofol overdose induces macrophage apoptosis through GSK-3β. METHODS Phagocytic… CONTINUE READING