Anesthetic properties of the ketone bodies beta-hydroxybutyric acid and acetone.

@article{Yang2007AnestheticPO,
  title={Anesthetic properties of the ketone bodies beta-hydroxybutyric acid and acetone.},
  author={Liya Yang and Jing Zhao and Pavle S. Milutinovic and Robert J Brosnan and Edmond I. Eger and James M. Sonner},
  journal={Anesthesia and analgesia},
  year={2007},
  volume={105 3},
  pages={
          673-9
        }
}
BACKGROUND We tested the hypothesis that two metabolites that are elevated in ketosis (beta-hydroxybutyric acid, and acetone) modulate ion channels in a manner similar to anesthetics and produce anesthesia in animals. METHODS alpha1beta2gamma2sgamma-aminobutyric acid type A (GABA(A)), alpha1 glycine, NR1/NR2A N-methyl-d-aspartate, and two pore domain TRESK channels were expressed in Xenopus laevis oocytes and studied using two-electrode voltage clamping. The effect of beta hydroxybutyric acid… CONTINUE READING

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