Anesthetic effects on the glycerol model of rhabdomyolysis-induced acute renal failure in rats.

@article{Lochhead1998AnestheticEO,
  title={Anesthetic effects on the glycerol model of rhabdomyolysis-induced acute renal failure in rats.},
  author={K M Lochhead and Evan D. Kharasch and Richard A Zager},
  journal={Journal of the American Society of Nephrology : JASN},
  year={1998},
  volume={9 2},
  pages={305-9}
}
Isoflurane, the most widely used inhalational anesthetic, releases inorganic fluoride during its metabolism by the cytochrome P450 system. Recent experimental data indicate that when cultured proximal tubular cells are exposed to inorganic fluoride, they become relatively resistant to myoglobin- and ATP depletion-mediated attack. The present study was undertaken to assess whether isoflurane anesthesia might confer in vivo cytoprotection, possibly by causing renal tubular inorganic fluoride… CONTINUE READING