Anesthetic effects on cerebral metabolic rate predict histologic outcome from near-complete forebrain ischemia in the rat.

@article{Nellgrd2000AnestheticEO,
  title={Anesthetic effects on cerebral metabolic rate predict histologic outcome from near-complete forebrain ischemia in the rat.},
  author={B M Nellg{\aa}rd and George Burkhard Mackensen and Javier Bello Pineda and John C. Wellons and Robert D. Pearlstein and David Sjoquist Nick Warner},
  journal={Anesthesiology},
  year={2000},
  volume={93 2},
  pages={431-6}
}
BACKGROUND Although reduction of cerebral metabolic rate is thought to contribute to anesthetic neuroprotection, histologic evidence to support this concept has not been provided. In this study, histologic outcome was evaluated in rats subjected to different durations of severe forebrain ischemia while anesthetized with volatile anesthetics that have substantially different effects on cerebral metabolic rate. METHODS Normothermic rats that underwent fasting were anesthetized with 0.75 minimum… CONTINUE READING

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Therapeutic coma or neuroprotection by anaesthetics.

Acta neurologica Belgica • 2000
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