Anesthetic Pharmacology and the Morbidly Obese Patient.

  title={Anesthetic Pharmacology and the Morbidly Obese Patient.},
  author={Jerry Ingrande and H. J. M. Lemmens},
  journal={Current anesthesiology reports},
  volume={3 1},
Anesthesiologists are increasingly being faced with treating obese patients. Physiologic and anthropometric associated with obesity-most notably increases in cardiac output, changes in tissue perfusion and increases in total body weight (TBW), lean body weight (LBW), and fat mass affect the pharmacokinetics (PK) of anesthetic agents. In addition, redundancy of airway tissue, obstructive and central sleep apnea and CO2 retention affect the pharmacodynamics (PD) of anesthetics and narrow the… CONTINUE READING

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