Anesthetic Induction with Etomidate, Rather than Propofol, Is Associated with Increased 30-Day Mortality and Cardiovascular Morbidity After Noncardiac Surgery

@article{Komatsu2013AnestheticIW,
  title={Anesthetic Induction with Etomidate, Rather than Propofol, Is Associated with Increased 30-Day Mortality and Cardiovascular Morbidity After Noncardiac Surgery},
  author={Ryu Komatsu and Jing You and Edward J. Mascha and Daniel I. Sessler and Yusuke Kasuya and Alparslan Turan},
  journal={Anesthesia \& Analgesia},
  year={2013},
  volume={117},
  pages={1329–1337}
}
BACKGROUND: Because etomidate impairs adrenal function and blunts the cortisol release associated with surgical stimulus, we hypothesized that patients induced with etomidate suffer greater mortality and morbidity than comparable patients induced with propofol. METHODS: We evaluated the electronic records of 31,148 ASA physical status III and IV patients who had noncardiac surgery at the Cleveland Clinic. Among these, anesthesia was induced with etomidate and maintained with volatile… 

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