Anesthesia-induced neuronal apoptosis during synaptogenesis: a review of the literature.

  title={Anesthesia-induced neuronal apoptosis during synaptogenesis: a review of the literature.},
  author={Grace Kline Loftis and Shawn Bryant Collins and Mason McDowell},
  journal={AANA journal},
  volume={80 4},
Anesthesia is generally accepted as safe in most adult populations; however, in pediatric patients questions exist regarding the potential for long-term detrimental effects. Various anesthetic agents are associated with neuronal degeneration when administered to neonatal animals. The mechanism of damage is thought to be via accelerated apoptosis, a normally beneficial process in the maintenance of homeostasis. This review of the literature examines the current evidence in neonatal rodents… CONTINUE READING

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Early childhood exposure to anesthesia and risk of developmental and behavioral disorders in a birth cohort of 5 , 824 twin pairs [ Abstract ISSA 1 ]

  • C Dimaggio, LS Sun, G Li
  • 2010

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