Anesthesia in children with osteogenesis imperfecta: Retrospective chart review of 83 patients and 205 anesthetics over 7 years

@article{Rothschild2018AnesthesiaIC,
  title={Anesthesia in children with osteogenesis imperfecta: Retrospective chart review of 83 patients and 205 anesthetics over 7 years},
  author={Leelach Rothschild and Jessica K Goeller and Polina Voronov and Alexandra Barabanova and Peter Smith},
  journal={Pediatric Anesthesia},
  year={2018},
  volume={28},
  pages={1050 - 1058}
}
Osteogenesis imperfecta is the collective term for a heterogeneous group of connective tissue syndromes characterized by bone fragility with multisystem involvement and perioperative implications. 
Comprehensive risk assessments and anesthetic management for children with osteogenesis imperfecta: A retrospective review of 252 orthopedic procedures over 5 years
Major anesthetic risks arise in orthopedic surgeries for children with osteogenesis imperfecta, a rare genetically inherited condition presenting diverse skeletal issues.
A retrospective study to evaluate the anaesthetic choices and complications for patients with osteogenesis imperfecta at a quaternary referral hospital
TLDR
Despite most patients in this study having severe OI, few of the complications and difficulties described in the literature were identified and a combined GA and RA technique with a SGAD was shown to be a safe anaesthesia technique.
Neuraxial and regional anesthesia in surgical patients with osteogenesis imperfecta: a narrative review of literature
TLDR
There is insufficient evidence to validate or refute the potential risks associated with the use of regional and neuraxial techniques in patients with OI, and further research is needed to adequately assess clinically relevant outcomes such as complications and opioid-sparing effect.
Osteogenesis Imperfecta Surgical Management of the Femur and Knee
TLDR
Avoiding significantly painful and potentially traumatic experiences is one of the main goals of surgical treatment for patients with OI, as well as decreasing the need for post-fracture immobilization, which causes further osteoporosis, weakness, and stiffness.
Osteogenesis Imperfecta: A Case-Based Guide to Surgical Decision-Making and Care
TLDR
Optimizing bone density and strength is recommended through nutritional, bisphosphonate, or other pharmacologic treatments and confirmation through bone density measurement as possible in conjunction with the multidisciplinary team.
Anesthetic and Post-operative Pain Management
TLDR
Careful planning is required to successfully manage OI patients and the anesthetic challenges they pose and avoid complications in these fragile patients.
Assessing bleeding risk in 18 children with Osteogenesis imperfecta
TLDR
The data show that patients with OI are not associated with von Willebrand disease, plasmatic coagulation or antifibrinolytic factor deficiencies predisposing to bleeding, suggesting that bleeding in those patients is not related to intrinsic platelet dysfunction.
MANAGEMENT OF ENDOCRINE DISEASE: Osteogenesis imperfecta: an update on clinical features and therapies.
TLDR
Clinically, OI is heterogeneous in features and variable in severity, and new strategies are being explored, such as sclerostin inhibitory antibodies and TGF beta inhibition, to address not only the low bone mineral density but also the inherent bone fragility.
Determinant Factors of the Quality of Life in Children with Osteogenesis Imperfecta during the COVID-19 Pandemic
TLDR
Fear of and obstacles to visiting the hospital and Supplementation of calcium and/or vitamin D pre and during the COVID-19 pandemic significantly impacted school functioning and the total score.
Osteogenesis imperfecta
Osteogenesis imperfecta (OI) beschreibt eine Gruppe seltener Erkrankungen, die mit erhöhter Knochenbruchneigung einhergehen. Neben dem Hauptsymptom der Frakturen ist OI durch eine Vielzahl
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References

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Anaesthesia for children with osteogenesis imperfecta – a review covering 30 years and 266 anaesthetics
TLDR
The concept that malignant hyperpyrexia is an associated condition is refuted although these patients may have an increased metabolic rate and a tendency to pyrexia.
Anesthetic considerations for the patient with osteogenesis imperfecta.
  • R. Libman
  • Medicine
    Clinical orthopaedics and related research
  • 1981
TLDR
Local or regional anesthesia is very useful in patients with osteogenesis imperfecta, but when general anesthesia is mandatory ketamine hydrochloride is often a good choice.
Anesthetic Management of Intramedullary Nailing in Osteogenesis Imperfecta: Report of a Case
STEOGE NESIS imperfecta (brittle bones 0 or Vrolik‘s disease) is an inherited disease of connective tissue,l with the skeletal system the most conspicuous target of the syndrome. It is a form of
Occurrence of malignant hyperpyrexia in a patient with osteogenesis imperfecta.
TLDR
This case illustrates the infrequently reported association of malignant hyperpyrexia with osteogenesis imperfecta, and the difficulties in obtaining an adequate personal and family history of previous anaesthetics.
Recent developments in osteogenesis imperfecta
TLDR
The genetics of OI and advances in the authors' understanding of the biomechanical properties of Oi bone are reviewed and current understanding of pharmacologic therapies for treatment of O I is discussed.
Airway management with ProSeal LMA in a patient with osteogenesis imperfecta.
TLDR
Fatal case of accidental intra-arterial phenytoin injection, followed by difficult intubation in a child with congenital muscular dystrophy.
Fatal intraoperative hemorrhage during spinal fusion surgery for osteogenesis imperfecta.
  • K. Sperry
  • Medicine
    The American journal of forensic medicine and pathology
  • 1989
TLDR
A case is presented here of a young girl with advanced OI in whom intraoperative death occurred as a consequence of inadvertent rib fractures, with subsequent uncontrollable hemorrhage.
Craniocervical abnormalities in osteogenesis imperfecta: Genetic and molecular correlation
TLDR
Basilar impression assessed by either plain lateral skull radiograph or computerized tomography sagittal reconstruction of the craniocervical junction is a common finding occurring in 25% of subjects with osteogenesis imperfecta (OI), and screening is recommended for all patients with OI but particularly OI type IVB.
Osteogenesis imperfecta.
TLDR
Although this treatment does not constitute a cure, it is an adjunct to physiotherapy, rehabilitation, and orthopaedic care, and Gene-based therapy presently remains in the early stages of preclinical research.
Incidence of Fractures From Perioperative Blood Pressure Cuff Use, Tourniquet Use, and Patient Positioning in Osteogenesis Imperfecta
TLDR
In pediatric patients with OI, intraoperative use of NIBP cuffs and tourniquets was not associated with iatrogenic fracture, and care should be used during the perioperative period to prevent fractures during body positioning.
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