Anergic bone marrow Vγ9Vδ2 T cells as early and long-lasting markers of PD-1-targetable microenvironment-induced immune suppression in human myeloma

@inproceedings{Castell2015AnergicBM,
  title={Anergic bone marrow Vγ9Vδ2 T cells as early and long-lasting markers of PD-1-targetable microenvironment-induced immune suppression in human myeloma},
  author={B. Femen{\'i}a Castell{\'a} and Myriam Foglietta and Patrizia Sciancalepore and Micol Maria Rigoni and Marta G. Coscia and Valentina Griggio and Candida Vitale and Riccardo Ferracini and Elona Saraci and Paola Omed{\'e} and Chiara Riganti and Antonio Palumbo and Mario Boccadoro and Massimo Massaia},
  booktitle={Oncoimmunology},
  year={2015}
}
Vγ9Vδ2 T cells have a natural inclination to recognize malignant B cells in vitro via receptors for stress-induced self-ligands and TCR-dependent recognition of phosphoantigens (pAgs) generated in the mevalonate (Mev) pathway. This inclination is continuously challenged in vivo by the immune suppression operated by tumor cells. Multiple myeloma (MM) is a prototypic B-cell malignancy in which myeloma cells subvert the local microenvironment to reshape antitumor immune responses. In this study… CONTINUE READING
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