Anergic T cells act as suppressor cells in vitro and in vivo.

  title={Anergic T cells act as suppressor cells in vitro and in vivo.},
  author={J G Chai and Istvan Bartok and Phillip Chandler and Silvia Vendetti and Antonis Antoniou and Julian P. Dyson and R. Lechler},
  journal={European journal of immunology},
  volume={29 2},
The potential suppressive effects of allospecific anergic T cells were investigated both in vitro and in vivo. Allospecific T cells were rendered unresponsive in vitro using immobilized anti-CD3 mAb. These anergic T cells profoundly inhibited proliferation of responsive T cells in an antigen-specific manner. The observed inhibition did not appear to be due to the release of inhibitory cytokines in that secretion of IL-2, IFN-gamma, IL-4, IL-10 and TGF-beta was greatly reduced following the… CONTINUE READING

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