Anendogenous tumour-promoting ligand of the human aryl hydrocarbon receptor

  title={Anendogenous tumour-promoting ligand of the human aryl hydrocarbon receptor},
  author={Christiane A Opitz and Ulrike M. Litzenburger and Felix Sahm and Martina Ott and Isabel Tritschler and Saskia Trump and Theresa Schumacher and Leonie Jestaedt and Dieter Schrenk and Michael Weller and Manfred Jugold and Gilles J Guillemin and Christine L Miller and Christian Lutz and Bernhard Radlwimmer and Irina Lehmann and Andreas von Deimling and Wolfgang Wick and Michael Platten},
Activation of the aryl hydrocarbon receptor (AHR) by environmental xenobiotic toxic chemicals, for instance 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin), has been implicated in a variety of cellular processes such as embryogenesis, transformation, tumorigenesis and inflammation. But the identity of an endogenous ligand activating the AHR under physiological conditions in the absence of environmental toxic chemicals is still unknown. Here we identify the tryptophan (Trp) catabolite kynurenine… CONTINUE READING
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