Anemia Offers Stronger Protection Than Sickle Cell Trait Against the Erythrocytic Stage of Falciparum Malaria and This Protection Is Reversed by Iron Supplementation

@inproceedings{Goheen2016AnemiaOS,
  title={Anemia Offers Stronger Protection Than Sickle Cell Trait Against the Erythrocytic Stage of Falciparum Malaria and This Protection Is Reversed by Iron Supplementation},
  author={M. M. Goheen and Rita Wegm{\"u}ller and Amat Bah and Bakary M Darboe and Ebrima Danso and Muna Affara and David Gardner and J. C. Patel and A. M. Prentice and Carla Cerami},
  booktitle={EBioMedicine},
  year={2016}
}
BACKGROUND Iron deficiency causes long-term adverse consequences for children and is the most common nutritional deficiency worldwide. Observational studies suggest that iron deficiency anemia protects against Plasmodium falciparum malaria and several intervention trials have indicated that iron supplementation increases malaria risk through unknown mechanism(s). This poses a major challenge for health policy. We investigated how anemia inhibits blood stage malaria infection and how iron… CONTINUE READING
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Iron Status and Associated Malaria Risk Among African Children.

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