Androstanediol glucuronide production in human liver, prostate, and skin. Evidence for the importance of the liver in 5 alpha-reduced androgen metabolism.

@article{Rittmaster1993AndrostanediolGP,
  title={Androstanediol glucuronide production in human liver, prostate, and skin. Evidence for the importance of the liver in 5 alpha-reduced androgen metabolism.},
  author={Roger S. Rittmaster and Hansruedi Zwicker and Deborah L. Thompson and G P Konok and Richard W. Norman},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1993},
  volume={76 4},
  pages={977-82}
}
Androstanediol glucuronide (Adiol G) has been reported to be a marker of peripheral androgen metabolism and action. It consists of two isomers, Adiol 3-G and Adiol 17-G. Adiol G is formed from unconjugated precursors by the enzyme glucuronyl transferase. To determine the likely source of Adiol G formation in man, we developed a glucuronyl transferase assay and measured the activity of this enzyme in human liver, abdominal and scalp skin, and prostate. In human liver, glucuronyl transferase… CONTINUE READING