• DOI:10.1039/J39700002473
Corpus ID: 208685821

Androsta-2,4-diene-6,17-dione.

@article{Hanson1970Androsta24diene617dione,
  title={Androsta-2,4-diene-6,17-dione.},
  author={J. Hanson and T. Organ},
  journal={Journal of the Chemical Society. Perkin transactions 1},
  year={1970},
  volume={18},
  pages={
          2473-5
        }
}

J. Hanson, T. Organ

Published 1970

Chemistry, Medicine

Journal of the Chemical Society. Perkin transactions 1

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Treatment of 5α,6α-epoxy-3β-methylsulphonyloxyandrostan-17-one with lithium bromide and lithium carbonate in dimethylformamide afforded androst-4-ene-6,17-dione. Dehydrogenation of this with dichlorodicyanobenzo-quinone gave androsta-2,4-diene-6,17-dione. This was also prepared by oxidation of the epoxide to the 5α-hydroxy-6-ketone followed by elimination of the methanesulphonate group with lithium carbonate and dehydration of the 5α-alcohol with thionyl chloride.