Andrographolide reduces inflammation-mediated dopaminergic neurodegeneration in mesencephalic neuron-glia cultures by inhibiting microglial activation.

@article{Wang2004AndrographolideRI,
  title={Andrographolide reduces inflammation-mediated dopaminergic neurodegeneration in mesencephalic neuron-glia cultures by inhibiting microglial activation.},
  author={Tongguang Wang and Bin Liu and Wei Zhang and Belinda C. Wilson and Jau-Shyong Hong},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2004},
  volume={308 3},
  pages={975-83}
}
Inflammation plays an important role in the pathogenesis of several neurodegenerative diseases, including Parkinson's disease. Recent reports have indicated that andrographolide (ANDRO) has an anti-inflammatory effect by modulating macrophage and neutrophil activity. Whereas microglia, the counterpart of macrophages in the brain, are pivotal in the inflammatory process in the central nervous system, the effect of ANDRO on inflammation-mediated neurodegeneration has not been examined. In this… CONTINUE READING

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