Andrographolide interferes with T cell activation and reduces experimental autoimmune encephalomyelitis in the mouse.

@article{Iruretagoyena2005AndrographolideIW,
  title={Andrographolide interferes with T cell activation and reduces experimental autoimmune encephalomyelitis in the mouse.},
  author={Mirentxu I. Iruretagoyena and Jaime A. Tobar and Pablo A Gonz{\'a}lez and Sof{\'i}a E. Sep{\'u}lveda and Claudio A. Figueroa and Rafael A Burgos and Juan L Hancke and Alexis M Kalergis},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2005},
  volume={312 1},
  pages={366-72}
}
Andrographolide is a bicyclic diterpenoid lactone derived from extracts of Andrographis paniculata, a plant indigenous to South Asian countries that shows anti-inflammatory properties. The molecular and cellular bases for this immunomodulatory capacity remain unknown. Here, we show that andrographolide is able to down-modulate both humoral and cellular adaptive immune responses. In vitro, this molecule was able to interfere with T cell proliferation and cytokine release in response to allogenic… CONTINUE READING

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