Andrographolide inhibits the adhesion of gastric cancer cells to endothelial cells by blocking E-selectin expression.

@article{Jiang2007AndrographolideIT,
  title={Andrographolide inhibits the adhesion of gastric cancer cells to endothelial cells by blocking E-selectin expression.},
  author={Cheng-gang Jiang and Jia-Bin Li and Fu-rong Liu and Tao Wu and Miao Yu and Huimian Xu},
  journal={Anticancer research},
  year={2007},
  volume={27 4B},
  pages={2439-47}
}
BACKGROUND Andrographolide, an active component isolated from the Chinese official herbal Andrographis paniculata, has recently been reported to have anticancer activity. However the molecular mechanism responsible for its anticancer action has not been fully defined. In this study, we investigated the effect of andrographolide on the adhesion of gastric cancer cells to the activated endothelial cells and the expression of some cell adhesion molecules. MATERIALS AND METHODS Human endothelial… CONTINUE READING

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