Andrographolide exerts anti-hepatitis C virus activity by up-regulating haeme oxygenase-1 via the p38 MAPK/Nrf2 pathway in human hepatoma cells.

@article{Lee2014AndrographolideEA,
  title={Andrographolide exerts anti-hepatitis C virus activity by up-regulating haeme oxygenase-1 via the p38 MAPK/Nrf2 pathway in human hepatoma cells.},
  author={J C Lee and Chin-Kai Tseng and Kung-Chia Young and Hung-Yu Sun and S Wang and Wei-Chun Chen and Chun-Kuang Lin and Yu-Hsuan Wu},
  journal={British journal of pharmacology},
  year={2014},
  volume={171 1},
  pages={237-52}
}
BACKGROUND AND PURPOSE This study aimed to evaluate the anti-hepatitis C virus (HCV) activity of andrographolide, a diterpenoid lactone extracted from Andrographis paniculata, and to identify the signalling pathway involved in its antiviral action. EXPERIMENTAL APPROACH Using HCV replicon and HCVcc infectious systems, we identified anti-HCV activity of andrographolide by measuring protein and RNA levels. A reporter activity assay was used to determine transcriptional regulation of anti-HCV… CONTINUE READING

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Significantly , these antiviral effects were attenuated by an HO-1-specific inhibitor or HO-1 gene knockdown , indicating that HO-1 contributed to the anti - HCV activity of andrographolide .
Andrographolide up - regulated the expression of haeme oxygenase-1 ( HO-1 ) , leading to increased amounts of its metabolite biliverdin , which was found to suppress HCV replication by promoting the antiviral IFN responses and inhibiting NS3/4A protease activity .
This study aimed to evaluate the anti - hepatitis C virus ( HCV ) activity of andrographolide , a diterpenoid lactone extracted from Andrographis paniculata , and to identify the signalling pathway involved in its antiviral action .
This study aimed to evaluate the anti - hepatitis C virus ( HCV ) activity of andrographolide , a diterpenoid lactone extracted from Andrographis paniculata , and to identify the signalling pathway involved in its antiviral action .
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