Andrographolide derivative AL-1 improves insulin resistance through down-regulation of NF-κB signalling pathway.

@article{Li2015AndrographolideDA,
  title={Andrographolide derivative AL-1 improves insulin resistance through down-regulation of NF-κB signalling pathway.},
  author={Yongmei Li and Hui Yan and Zaijun Zhang and Gaoxiao Zhang and Yewei Sun and Pei Yu and Yuqiang Wang and Lipeng Xu},
  journal={British journal of pharmacology},
  year={2015},
  volume={172 12},
  pages={3151-8}
}
BACKGROUND AND PURPOSE Andrographolide is the most active constituent of the medicinal plant Andrographis paniculata. Previously, we synthesized a novel andrographolide derivative AL-1, conjugating andrographolide with lipoic acid. Although the antioxidative and/or anti-inflammatory activity of AL-1 contributes to its cytoprotective effects, whether AL-1 can improve insulin resistance and the mechanisms responsible for its action have not been elucidated. EXPERIMENTAL APPROACH We investigated… CONTINUE READING

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