Andrographolide and analogues in cancer prevention.

@article{Mishra2015AndrographolideAA,
  title={Andrographolide and analogues in cancer prevention.},
  author={S. Mishra and S. Tripathi and A. Shukla and S. Oh and Hwan-Mook Kim},
  journal={Frontiers in bioscience},
  year={2015},
  volume={7},
  pages={
          255-66
        }
}
Andrographis paniculata is a medicinal plant traditionally used for treatment of cough and cold, fever, laryngitis, and several infectious diseases. Extracts of A. paniculata have shown versatile potency against various diseases including cancer. The active biomolecules of A. paniculata mainly are lactone and diterpene. Andrographolide and analogues have been widely used for prevention of different diseases. Andrographolides have shown potent antiinflammatory and anticancer activities. It… Expand
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The results suggest that andrographolide is an interesting pharmacophore with anticancer and immunomodulatory activities and hence has the potential for being developed as a cancer therapeutic agent. Expand
Andrographolide exhibits anti-invasive activity against colon cancer cells via inhibition of MMP2 activity.
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It is demonstrated that andrographolide at nontoxic to subtoxic concentrations (0.3-3 µM) suppressed the invasion ability of CT26 cells in Matrigel-based invasion assays and exhibits anti-invasive activity against colon cancer cells via inhibition of MMP2 activity. Expand
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The study indicates that the regenerative capability elicited by andrographolide is possibly due to its ability to reactivate liver function enzymes that catalyze the reaction of several biochemical and synthetic processes and that it may be useful for severe liver damage conditions. Expand
Andrographolide, an herbal medicine, inhibits interleukin-6 expression and suppresses prostate cancer cell growth.
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Results demonstrate that andrographolide could be developed as a therapeutic agent to treat both androgen-stimulated and castration-resistant prostate cancer possibly by suppressing IL-6 expression and IL- 6-induced signaling. Expand
Andrographolide inhibits osteopontin expression and breast tumor growth through down regulation of PI3 kinase/Akt signaling pathway.
TLDR
Andro, a natural diterpenoid lactone isolated from Andrographis paniculata has been shown to inhibit breast cancer cell proliferation, migration and arrest cell cycle at G2/M phase and induces apoptosis through caspase independent pathway, demonstrating that Andro may act as an effective anti-tumor and anti-angiogenic agent for the treatment of breast cancer. Expand
Andrographolide Inhibits Oral Squamous Cell Carcinogenesis through NF-κB Inactivation
TLDR
It is reported that Andro, but not its inactive structural analog 4H-Andro, potently suppressed squamous cell carcinogenesis induced by 7,12-dimethyl-1,2-benzanthracene (DMBA) in the hamster model of cheek buccal pouch. Expand
Andrographis paniculata extracts and major constituent diterpenoids inhibit growth of intrahepatic cholangiocarcinoma cells by inducing cell cycle arrest and apoptosis.
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Andrographis paniculata could be a promising herbal plant for the alternative treatment of intrahepatic cholangiocarcinoma because of its potent cytotoxic activity against the growth of liver and bile duct cancer cells. Expand
Andrographolide sensitizes cisplatin-induced apoptosis via suppression of autophagosome-lysosome fusion in human cancer cells
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It is suggested that Andro could be a promising anti-cancer agent in combination therapy via its potent inhibitory effect on autophagy by disrupting autophagosome-lysosome fusion. Expand
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TLDR
Results suggested Andro can inhibit Lovo cell growth by G1-S phase arrest, and was exerted by inducing the expression of p53, p21 and p16 that repressed the activity of Cyclin D1/C DK4 and/or Cyclin A/Cdk2, as well as Rb phosphorylation. Expand
Andrographolide sensitizes cancer cells to TRAIL-induced apoptosis via p53-mediated death receptor 4 up-regulation
TLDR
It is shown that pretreatment with Andro significantly enhances TRAIL-induced apoptosis in various human cancer cell lines, including those TRAil-resistant cells, and the tumor suppressor p53 plays an essential role in DR4 transcriptional activation. Expand
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