Andrographolide Protects against LPS-Induced Acute Lung Injury by Inactivation of NF-κB

  title={Andrographolide Protects against LPS-Induced Acute Lung Injury by Inactivation of NF-κB},
  author={Tao Zhu and Dao-xin Wang and Wei Zhang and Xiu-qing Liao and Xian Guan and Hong Bo and Jia-yang Sun and Ni-wen Huang and Jing He and Yun-kun Zhang and Jing Tong and Chang-yi Li},
  booktitle={PloS one},
BACKGROUND Nuclear factor-κB (NF-κB) is a central transcriptional factor and a pleiotropic regulator of many genes involved in acute lung injury. Andrographolide is found in the plant of Andrographis paniculata and widely used in Traditional Chinese Medicine, exhibiting potently anti-inflammatory property by inhibiting NF-κB activity. The purpose of our investigation was designed to reveal the effect of andrographolide on various aspects of LPS induced inflammation in vivo and in vitro… CONTINUE READING
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