Andrographolide: A potent antituberculosis compound that targets Aminoglycoside 2'-N-acetyltransferase in Mycobacterium tuberculosis.

@article{Prabu2015AndrographolideAP,
  title={Andrographolide: A potent antituberculosis compound that targets Aminoglycoside 2'-N-acetyltransferase in Mycobacterium tuberculosis.},
  author={Amudha Prabu and Sameer Hassan and Prabuseenivasan and A S Shainaba and Luke Elizabeth Hanna and Vanaja Kumar},
  journal={Journal of molecular graphics & modelling},
  year={2015},
  volume={61},
  pages={133-40}
}
Tuberculosis (TB) still remains a major challenging infectious disease. The increased rate of emergence of multi-drug resistant and extensively-drug resistant strains of the organism has further complicated the situation, resulting in an urgent need for new anti-TB drugs. Antimycobacterial activity of Andrographis paniculata was evaluated using a rapid LRP assay and the probable targets were identified by docking analysis. The methanolic extract of A. paniculata showed maximum antimycobacterial… CONTINUE READING