• Corpus ID: 29490898

Andrographis paniculata downregulates proinflammatory cytokine production and augments cell mediated immune response in metastatic tumor-bearing mice.

@article{Sheeja2010AndrographisPD,
  title={Andrographis paniculata downregulates proinflammatory cytokine production and augments cell mediated immune response in metastatic tumor-bearing mice.},
  author={K. R. Sheeja and Girija Kuttan},
  journal={Asian Pacific journal of cancer prevention : APJCP},
  year={2010},
  volume={11 3},
  pages={
          723-9
        }
}
  • K. Sheeja, G. Kuttan
  • Published 2010
  • Biology, Medicine
  • Asian Pacific journal of cancer prevention : APJCP
Effects of Andrographis paniculata extract and its major component, andrographolide, on cell-mediated immune responses in metastatic tumor bearing animals were studied. NK cell mediated target cell lysis was enhanced by the administration of Andrographis paniculata extract (45.0% cell lysis) and andrographolide (40.2% cell lysis) on the 5th day after tumor induction when compared to untreated metastatic tumor bearing animals in which maximum target cell lysis was observed on 11th day (11.4… 

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References

SHOWING 1-10 OF 31 REFERENCES
Hepatoprotective activity of andrographolide from Andrographis paniculata against carbontetrachloride.
TLDR
The results suggest that andrographolide is the major active antihepatotoxic principle present in A. paniculata.
Andrographolide prevents oxygen radical production by human neutrophils: possible mechanism(s) involved in its anti‐inflammatory effect
TLDR
The prevention of ROS production through, at least in part, modulation of PKC‐dependent pathway could confer ANDRO the ability to down‐regulate Mac‐1 up‐expression that is essential for neutrophil adhesion and transmigration.
Anti-diabetic property of ethanolic extract of Andrographis paniculata in streptozotocin-diabetic rats.
TLDR
The ethanolic extract of A paniculata possesses antidiabetic property and may be attributed at least in part to increased glucose metabolism, which is beneficial in the diabetic state.
Is mda-7/IL-24 a "magic bullet" for cancer?
TLDR
Ability to discriminate between normal and cancer cells, induce apoptosis in diverse tumor cells, promote "bystander" antitumor effects, inhibit tumor growth and angiogenesis in animal models, synergize with radiation, and modulate immune responses enable this gene as an effective therapy for cancer.
Granulocyte-colony stimulating factor enhances chimeric antibody Nd2 dependent cytotoxicity against pancreatic cancer mediated by polymorphonuclear neutrophils.
TLDR
The results suggest that PMNs play an important role in c-Nd2 inducing ADCC and that combination immunotherapy of c- Nd2 with G-CSF may have clinical applications in the treatment of patients with pancreatic cancer by enhancing ADCC.
Suppressor cells: permitters and promoters of malignancy?
  • D. Naor
  • Biology
    Advances in cancer research
  • 1979
Targeted anti-interleukin-6 monoclonal antibody therapy for cancer: a review of the rationale and clinical evidence.
TLDR
In six clinical studies of mAbs to IL-6 with BE-8 or CNTO 328 in patients with multiple myeloma, renal cell carcinoma, and B-lymphoproliferative disorders, anti-IL-6 mAb treatment decreased C-reactive protein levels in all patients, and the antibodies were well tolerated, and no serious adverse effects were observed in the vast majority of studies.
A critical role for the inflammatory response in a mouse model of preneoplastic progression.
TLDR
Activation of inducible fibroblast growth factor receptor-1 in the mammary epithelium rapidly increased the expression of several genes involved in the inflammatory response, and conditional depletion of macrophages inhibited iFGFR1-mediated epithelial cell proliferation and lateral budding.
...
1
2
3
4
...