Androgens suppress osteoclast formation induced by RANKL and macrophage-colony stimulating factor.

@article{Huber2001AndrogensSO,
  title={Androgens suppress osteoclast formation induced by RANKL and macrophage-colony stimulating factor.},
  author={Dr. Michael Huber and Amy C. Bendixen and Peterson Pathrose and Smita Srivastava and Krista M. Dienger and Nirupama K. Shevde and John Wesley Pike},
  journal={Endocrinology},
  year={2001},
  volume={142 9},
  pages={3800-8}
}
Androgen deficiency in males leads to an increase in osteoclastic bone resorption and a progressive decrease in bone mineral density. In the current studies, we examined the ability of 5 alpha-dihydrotestosterone to suppress osteoclast formation induced by receptor activator of NF-kB ligand (RANKL) and macrophage-colony stimulating factor in vitro. 5 alpha-Dihydrotestosterone suppressed the differentiation of bone marrow monocytes into osteoclasts from both sham-operated and orchidectomized… CONTINUE READING