Androgens inhibit the stimulatory action of 17β-estradiol on normal human breast tissue in explant cultures.

@article{Eiglien2012AndrogensIT,
  title={Androgens inhibit the stimulatory action of 17β-estradiol on normal human breast tissue in explant cultures.},
  author={Natalija Eigėlienė and Teresa Elo and Mari Linhala and Saija Hurme and Risto U Erkkola and Pirkko L. H{\"a}rk{\"o}nen},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2012},
  volume={97 7},
  pages={
          E1116-27
        }
}
BACKGROUND The data concerning the effects and safety of androgen in human breast tissue are conflicting. OBJECTIVE Our aim was to analyze the effects of androgens on normal human breast tissue (HBT). APPROACH We cultured explants of HBT (obtained from reduction mammoplasty operations of postmenopausal women) with or without testosterone (T) and 5α-dihydrotestosterone (DHT) or in combination with 17β-estradiol (E(2)) for 7 and 14 d to study the effects of androgens on proliferation… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 21 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 41 REFERENCES

Androgen receptor expression is significantly associated with better outcomes in estrogen receptor-positive breast cancers.

  • Annals of oncology : official journal of the European Society for Medical Oncology
  • 2011
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Dehydroepiandrosterone, androgens and the mammary gland.

  • Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
  • 2006
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Testosterone inhibits estrogen-induced mammary epithelial proliferation and suppresses estrogen receptor expression.

  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2000
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Amphiregulin is an essential mediator of estrogen receptor alpha function in mammary gland development.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2007
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL

Androgens and breast cancer in men and women.

  • Endocrinology and metabolism clinics of North America
  • 2011
VIEW 1 EXCERPT