Androgens in women are essentially made from DHEA in each peripheral tissue according to intracrinology

  title={Androgens in women are essentially made from DHEA in each peripheral tissue according to intracrinology},
  author={Fernand Labrie and C{\'e}line Martel and Alain Bélanger and Georges Pelletier},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},

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Is dehydroepiandrosterone a hormone?
The new field of intracrinology or local formation of sex steroids from DHEA in target tissues has permitted major advances in the treatment of the two most frequent cancers, namely breast and prostate cancer, while its potential use as a physiological HRT could well provide a physiological balance of androgens and estrogens, thus offering exciting possibilities for women's health at menopause.
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Impact of circulating dehydroepiandrosterone on androgen formation in women.
The most reliable estimate of the impact of changes in serum DHEA on global androgenic activity can be best derived from the data obtained in men where intratissular concentrations of androgens, namely testosterone and dihydrotestosterone (DHT), could be measured in the prostate before and after castration, thus making it possible to perform a precise and reliable calculation.
DHEA and intracrinology at menopause, a positive choice for evolution of the human species
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The presence of subthreshold levels of circulating estradiol combined with the formation of sex steroids from DHEA in specific peripheral tissues (intracrinology) makes menopause a positive characteristic supporting many years of good-quality postmenopausal life, useful for taking care of children and grandchildren.
Wide distribution of the serum dehydroepiandrosterone and sex steroid levels in postmenopausal women: role of the ovary?
The 7.9-fold difference between low and high serum DHEA levels provides an explanation for the lack of signs of hormone deficiency in some women, whereas most of them have symptoms or signs, thus indicating that all sex steroids originate from circulating D HEA in postmenopausal women with no direct secretion of active estrogens or androgens by the post menopausal ovary.
Physiological changes in dehydroepiandrosterone are not reflected by serum levels of active androgens and estrogens but of their metabolites: intracrinology.
The present study demonstrates that the serum concentrations of testosterone, DHT, E1, and E2 are poor indicators of total androgenic and estrogenic activity, and the esterified metabolites of DHT appear as reliable markers of the total androgens pool.
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