Androgens in the Feedback Regulation of Gonadotropin Secretion in Men: Effects of Administration of Dihydrotestosterone to Eugonadal and Agonadal Subjects and of Spironolactone to Eugonadal Subjects *

  title={Androgens in the Feedback Regulation of Gonadotropin Secretion in Men: Effects of Administration of Dihydrotestosterone to Eugonadal and Agonadal Subjects and of Spironolactone to Eugonadal Subjects *},
  author={Louis J Gooren and Eduard A. Veen and H. van Kessel and W Harmsen-Louman and A R Wiegel},
Summary: To study the role of androgens in the feedback regulation of gonadotropin secretion, we measured the effects of administration of dihydrotestosterone undecanoate (DHTU) and of spironolactone. 

The direct pituitary effect of testosterone to inhibit gonadotropin secretion in men is partially mediated by aromatization to estradiol.

It was found that administration of each steroid increased serum levels of the infused steroid to the upper physiologic range, suggesting that some of the direct effect of T at the pituitary level in men is mediated by E2, whereas peripherally formed DHT may not play an important role in this process.

Differential regulation of gonadotropin secretion by testosterone in the human male: absence of a negative feedback effect of testosterone on follicle-stimulating hormone secretion.

Both treatment regimens were associated with a significant increase in gonadotropin levels and distinguish the feedback effects of T that that are direct (i.e. mediated by the androgen receptor) vs. indirect (mediated by aromatization to E(2).

Human male sexual functions do not require aromatization of testosterone: A study using tamoxifen, testolactone, and dihydrotestosterone

  • L. Gooren
  • Biology, Medicine
    Archives of sexual behavior
  • 1985
It is concluded that aromatization of testosterone is not required and that dihydrotestosterone maintains sexual functions in the adult male with an established sex life.

Luteinizing hormone pulsatility in subjects with 5-alpha-reductase deficiency and decreased dihydrotestosterone production.

It is suggested that a deficiency of DHT results in decreased negative feedback at the level of the hypothalamus and/or pituitary, resulting in an increase in mean plasma LH, LH pulse amplitude, and LH responsiveness to GnRH, and a role for DHT in the modulation of LH is suggested.

Suppressive effects of Momordica charantia on pituitary-testicular axis and sperm production in male Sprague-Dawley rats

M. charantia seed extract suppresses the pituitary-testicular axis and sperm production in male rats and could be developed to a contraceptive drug for men.




Effects on plasma T, DHT, A, FSH, LH and PRL concentrations and the pituitary responsiveness to the LHRH/TRH stimulation, as well as on libido and sexual, mental and physical activities were studied

On the role of dihydrotestosterone in regulating luteinizing hormone secretion in man.

It seems unlikely that circulating DHT plays an important role in the physiological regulation of LH secretion, as high levels of plasma DHT, maintained over a long period, were unable to lower plasma LH in either normal or hypogonadal patients.

Androgen and estrogen effects on the regulation of LH in man.

Investigation of androgen and estrogen effects in the regulation of luteinizing hormone (LH) in man revealed that both androgens and estrogens are capable of exerting independent effects on LH secretion.

Studies on the role of sex steroids in the feedback control of gonadotropin concentrations in men. II. Use of the estrogen antagonist, clomiphene citrate.

Estradiol infusion in dosages equivalent to that derived from the infused T resulted in a decline in serum LH which was 60% of that seen with T, indicating that most of the Tmediated LH suppression could be attributed to its aromatization to E.

Effect of spironolactone on sex hormones in man.

Findings are consistent with a previously-reported spironolactone-induced destruction of the microsomal enzyme cytochrome P-450, an enzyme necessary for 17-hydroxylase and desmolase activity and do not explain the decrease of libido, the impotence, and the gynecomastia frequently associated with spironOLactone therapy in males.

Studies on the role of sex steroids in the feedback control of gonadotropin concentrations in men. III. Androgen resistance in primary gonadal failure.

ABSTRACT The negative feedback control of serum gonadotropins by sex steroids was studied in eight men with Leydig cell insufficiency, four of whom had diminished and four with unmeasurable Leydig

Evidence that testosterone can suppress pituitary gonadotropin secretion independently of peripheral aromatization.

The hypothesis that T or one of its metabolites can modulate LH and FSH secretion independently of peripheral aromatization to E is supported, as well as the pattern of plasma steroids, increased T and unchanged E.

Effect of spironolactone on androgen-dependent proteins in the ventral prostate of the rat.

The mechanism by which spironolactone exerts its anti-androgenic activity was shown to be unrelated to its capacity to inhibit the synthesis or accumulation of the five androgen-dependent proteins studied in this investigation.

The effect of flutamide on testosterone metabolism and the plasma levels of androgens and gonadotropins.

The patients showed a profound change in the peripheral metabolism of testosterone: markedly increased conversion to androsterone (A) and correspondingly decreased conversion to etiocholanolone (E); the A/E ratio rose to levels never before observed consistently in any group of healthy or diseased humans.


It is concluded that treatment with spironolactone for 2–4 days will lead to a transient rise in plasma T and urinary DHA, accompanied by increased androgen catabolism and a slightly increased conversion of androgens to oestrogens.