Androgens in Postmenopausal Women: Production, Possible Role, and Replacement Options

  title={Androgens in Postmenopausal Women: Production, Possible Role, and Replacement Options},
  author={Rogerio A. Lobo},
  journal={Obstetric and Gynecologic Survey},
  • R. Lobo
  • Published 1 June 2001
  • Medicine, Biology
  • Obstetric and Gynecologic Survey
The physiology of normal androgen production in women has not been well understood. Aging, per se, accounts for much of the reduction in both ovarian and adrenal androgen production; and natural menopause does not result in an abrupt decline in testosterone production. Therefore, the definition of an androgen deficiency state in women, in the absence of adrenal suppression and/or bilateral oophorectomy, has been difficult. Nevertheless there are well-documented beneficial effects of androgen on… 

Revisiting the physiological role of androgens in women

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The role of androgen therapy.

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  • Medicine, Biology
    Best practice & research. Clinical obstetrics & gynaecology
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The role of androgens in hormone replacement therapy

Understanding the long-term safety and efficacy of physiological androgen replacement and the development of sensitive testosterone assays for specific use in women will better characterise women who are most likely to respond to androgen therapy and, thereby, optimise their quality of life.

The role of androgen therapy.

  • S. DavisH. Burger
  • Medicine, Biology
    Best practice & research. Clinical endocrinology & metabolism
  • 2003
Clinical symptoms of androgen insufficiency include loss of libido, diminished well-being, fatigue and blunted motivation and have been reported to respond well to T replacement, generally without significant side-effects.

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Testosterone's effects on sexual function, cognitive function, muscle mass, body composition, and immune function in postmenopausal women are reviewed.

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Randomized, double-blind, placebo-controlled studies have established the efficacy of the transdermal testosterone patch for relieving symptoms of HSDD in surgically and naturally menopausal women with and without concomitant estrogen or estrogen/progestin therapy.

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Which androgen replacement therapy for women?

It is concluded that such transdermal systems may be of value for androgen therapy in postmenopausal women because they provide a highly controllable way of delivering T noninvasively and reliably, and achieve mean physiological levels not possible with existing methods.


The physician sees many women in the postmenopausal period who complain of fatigue, depression, arthralgia, headaches, insomnia, forgetfulness, and loss of libido-subtle indications of changes in mind and body accompanying the alteration in endocrine secretion, and alleviation of symptoms has been accomplished by the administration of androgen and estrogen in the respective sexes.

Evaluation of an estrogen, androgen, estrogen-androgen combination, and a placebo in the treatment of the menopause.

To establish the comparative effectiveness of a placebo, an estrogen, an androgen, and a combination of estrogen and androgen in the management of symptoms of the menopausal syndrome, a large number of therapeutic agents were used.

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Effects of replacement dose of dehydroepiandrosterone in men and women of advancing age.

Repairing DHEA and DS to young adult levels in men and women of advancing age induced an increase in the bioavailability of IGF-I, as reflected by an increases in IGF- I and a decrease in IGFBP-1 levels.

Androgen enhances sexual motivation in females: a prospective, crossover study of sex steroid administration in the surgical menopause.

It was clear that exogenous androgen enhanced the intensity of sexual desire and arousal and the frequency of sexual fantasies in hysterectomized and oophorectomization women, but there was no evidence that testosterone affected physiologic response or interpersonal aspects of sexual behavior.

Suppression of postmenopausal ovarian steroidogenesis with the luteinizing hormone-releasing hormone agonist goserelin.

The continued dependence of ovarian androgen secretion on gonadotropin stimulation after the menopause may explain the responses of some patients to LHRH agonists and some other therapeutic agents of unknown or uncertain modes of action.

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