Androgens in Postmenopausal Women: Production, Possible Role, and Replacement Options

@article{Lobo2001AndrogensIP,
  title={Androgens in Postmenopausal Women: Production, Possible Role, and Replacement Options},
  author={Rogerio A. Lobo},
  journal={Obstetric and Gynecologic Survey},
  year={2001},
  volume={56},
  pages={361-376}
}
  • R. Lobo
  • Published 1 June 2001
  • Medicine, Biology
  • Obstetric and Gynecologic Survey
The physiology of normal androgen production in women has not been well understood. Aging, per se, accounts for much of the reduction in both ovarian and adrenal androgen production; and natural menopause does not result in an abrupt decline in testosterone production. Therefore, the definition of an androgen deficiency state in women, in the absence of adrenal suppression and/or bilateral oophorectomy, has been difficult. Nevertheless there are well-documented beneficial effects of androgen on… 
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Androgens and the breast
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A literature review evaluating current clinical, genetic and epidemiological data regarding the role of androgens in mammary growth and neoplasia found that addition of testosterone to the usual hormone therapy regimen may diminish the estrogen/progestin increase in breast cancer risk but the impact of this combined use on mammary gland homeostasis still needs evaluation.
Sexuality in the climacteric years.
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TLDR
It is concluded that such transdermal systems may be of value for androgen therapy in postmenopausal women because they provide a highly controllable way of delivering T noninvasively and reliably, and achieve mean physiological levels not possible with existing methods.
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