Androgens decrease plasma adiponectin, an insulin-sensitizing adipocyte-derived protein.

@article{Nishizawa2002AndrogensDP,
  title={Androgens decrease plasma adiponectin, an insulin-sensitizing adipocyte-derived protein.},
  author={Hitoshi Nishizawa and Iichiro Shimomura and Ken Kishida and Norikazu Maeda and Hiroshi Kuriyama and Hiroyuki Nagaretani and Morihiro Matsuda and Hidehiko Kondo and Naoki Furuyama and Shinji Kihara and Tadashi Nakamura and Yoshihiro Tochino and Tohru Funahashi and Yuji Matsuzawa},
  journal={Diabetes},
  year={2002},
  volume={51 9},
  pages={2734-41}
}
Adiponectin, an adipose-specific secretory protein, exhibits antidiabetic and antiatherogenic properties. In the present study, we examined the effects of sex hormones on the regulation of adiponectin production. Plasma adiponectin concentrations were significantly lower in 442 men (age, 52.6 +/- 11.9 years [mean +/- SD]) than in 137 women (53.2 +/- 12.0 years) but not different between pre- and postmenopausal women. In mice, ovariectomy did not alter plasma adiponectin levels. In contrast… CONTINUE READING