Androgens augment proximal tubule transport.

  title={Androgens augment proximal tubule transport.},
  author={Albert W. Quan and Sumana Chakravarty and Jian-kang Chen and Jian-Chun Chen and Samer Loleh and Neel Saini and Ray Harris and J. Capdevila and Raymond Quigley},
  journal={American journal of physiology. Renal physiology},
  volume={287 3},
The proximal tubule contains an autonomous renin-angiotensin system that regulates transport independently of circulating angiotensin II. Androgens are known to increase expression of angiotensinogen, but the effect of androgens on proximal tubule transport is unknown. In this in vivo microperfusion study, we examined the effect of androgens on proximal tubule transport. The volume reabsorptive rate in Sprague-Dawley rats given dihydrotestosterone (DHT) injections was significantly higher than… CONTINUE READING