Androgens and puberty

  title={Androgens and puberty},
  author={Alan D. Rogol},
  journal={Molecular and Cellular Endocrinology},
  • A. Rogol
  • Published 30 December 2002
  • Biology
  • Molecular and Cellular Endocrinology
Androgens during Infancy, Childhood, and Adolescence: Physiology and use in clinical practice.
We provide an in-depth review of the role of androgens in male maturation and development from the fetal stage through adolescence into emerging adulthood and discuss the treatment of disorders of
The Pelvis During Childhood and Puberty
The intriguing question on mono-ovulation in women is discussed in this chapter and the basic developmental concept is the female one, small deviations of the needed male hormone concentrations induce already malformations.
Neurobiology of puberty and its disorders.
Androgen Actions on Bone: Clinical Aspects
The declining sex steroid levels in the elderly may adversely affect the preservation of skeletal integrity and indicates that aromatisation of testosterone to estradiol is an important mediator of bone metabolism inThe elderly.
Androgens in the demography of male life course ‐ A review
Testosterone supplementation in the aging male is able to restore the function of androgen target organs only in part, and the role of testosterone in male life course is still poorly understood.
Changes in bone mineral density during puberty
Puberty is the fundamental period for bone mass acquisition. In this period mineralization is found to increase with levels of high bone formation.. The objective of this cross-sectional study was to
Genetic, environmental and life-style effects on androgen receptor function
The median AR CAG number had the highest activity in vivo and in vitro and was negatively associated with semen volume in smoking men, indicating a stronger resistance for the median CAG length to these compounds compared to less common variants.
Age and sex relationship with flow-mediated dilation in healthy children and adolescents.
The brachial artery increases structurally with age in both sexes; however, there are sex differences in the timing and rate of growth, in line with typical sex-specific adolescent growth patterns.


Androgen-stimulated pubertal growth: the effects of testosterone and dihydrotestosterone on growth hormone and insulin-like growth factor-I in the treatment of short stature and delayed puberty.
The increase in GH at puberty in males appears to be due to an estrogen-dependent mechanism, and the suppressive effect of DHT on GH secretion may bedue to either suppression of estradiol production or a direct effect.
Hormonal changes in puberty. 3. Correlation of plasma testosterone, LH, FSH, testicular size, and bone age with male pubertal development.
The somatic manifestations of puberty in a cohort of 51 boys were correlated with changes in the concentrations of plasma testosterone, LH, and FSH, and a considerable variation in plasma hormone values was noted in P2 and P3.
Linear growth as a function of age at onset of puberty and sex steroid dosage: therapeutic implications.
How hormonal changes at puberty and the age of their occurrence influence growth rate and adult height has practical implications including timing and dosage of sex steroid replacement therapy in hypogonadal patients and the use of GnRH agonists in patients with precocious puberty or short stature.
Alterations in growth and body composition during puberty: III. Influence of maturation, gender, body composition, fat distribution, aerobic fitness, and energy expenditure on nocturnal growth hormone release.
Bone age and gender were the significant predictors of AUC, sigma GH peak heights, and mean nadir, and gender differences appear to be because of differences in estradiol concentrations rather than to body composition or body fat distribution.
Changes in growth and serum growth hormone and plasma somatomedin-C levels during suppression of gonadal sex steroid secretion in girls with central precocious puberty.
Suppression of gonadal sex steroid secretion in children with central precocious puberty (CPP) by LHRH analogs affords an opportunity to study sex steroid modulation of GH and somatomedin-C (Sm-C)
Pubertal staging in boys.
Interrelation of the therapeutic effects of growth hormone and testosterone on growth in hypopituitarism.
Gonadotrophin and Growth Hormone Secretion Throughout Puberty
There was a clear increase in the secretion of FSH during day and night from stage 2 onwards and the increase in GH secretion did not appear to be related to the rise in LH secretion, but rather to changes in the sex steroids.