Androgens and male physiology the syndrome of 5α-reductase-2 deficiency

@article{ImperatoMcGinley2002AndrogensAM,
  title={Androgens and male physiology the syndrome of 5$\alpha$-reductase-2 deficiency},
  author={J. Imperato-McGinley and Y. S. Zhu},
  journal={Molecular and Cellular Endocrinology},
  year={2002},
  volume={198},
  pages={51-59}
}
Abstract Dihydrotestosterone (DHT), a potent androgen, is converted from testosterone by 5α-reductase isozymes. There are two 5α-reductase isozymes, type 1 and type 2 in humans and animals. These two isozymes have differential biochemical and molecular features. Mutations in type 2 isozyme cause male pseudohermaphroditism, and many mutations have been reported from various ethnic groups. The affected 46XY individuals have high normal to elevated plasma testosterone levels with decreased DHT… Expand
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