Androgens and breast cancer

@article{Kotsopoulos2012AndrogensAB,
  title={Androgens and breast cancer},
  author={Joanne Kotsopoulos and Steven A. Narod},
  journal={Steroids},
  year={2012},
  volume={77},
  pages={1-9}
}
The role of androgens on breast cancer development and progression has not been fully elucidated. Several in vivo and in vitro studies demonstrate that androgens have an inhibitory effect on the mammary epithelium, whereas the majority of epidemiological studies report a positive association between high androgen levels and risk of breast cancer. Expression of the androgen receptor is a positive prognostic factor. Understanding the role of androgens in breast carcinogenesis is important because… 
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References

SHOWING 1-10 OF 138 REFERENCES
Androgens and the breast
TLDR
A literature review evaluating current clinical, genetic and epidemiological data regarding the role of androgens in mammary growth and neoplasia found that addition of testosterone to the usual hormone therapy regimen may diminish the estrogen/progestin increase in breast cancer risk but the impact of this combined use on mammary gland homeostasis still needs evaluation.
Androgens and androgen receptors in breast cancer
TLDR
Supporting evidence is discussed which proposes that androgens themselves are actively involved in breast carcinogenesis and its clinical behaviour and emerging evidence suggests that direct androgenic activity might also stimulate cell growth in a subset of estrogen-resistant breast tumors.
Testosterone and the breast
TLDR
The preponderance of data suggests that T use in females is not associated with an increased risk of breast carcinoma, and high-dose androgen therapy also has been effective in treating patients with advanced breast cancer.
Roles of androgens in the development, growth, and carcinogenesis of the mammary gland
  • D. Liao, R. Dickson
  • Medicine, Biology
    The Journal of Steroid Biochemistry and Molecular Biology
  • 2002
TLDR
It is proposed that concomitant elevation in both androgens and estrogens may confer a greater risk for tumorigenesis of the mammary gland, and probably other female reproductive tissues than an elevation of each hormone alone.
Androgens and mammary growth and neoplasia.
TLDR
Clinical and nonhuman primate studies suggest that androgens inhibit mammary epithelial proliferation and breast growth and that conventional estrogen treatment suppresses endogenous androgens.
Triple-Negative Breast Cancer: Role of the Androgen Receptor
TLDR
The role of the AR in breast cancer tumorigenesis and current progress and future directions in the development of AR-targeted therapies are reviewed.
Estrogen and the risk of breast cancer.
TLDR
Experimental data strongly suggest that estrogens have a role in the development and growth of breast cancer and the alkylation of cellular molecules and the generation of new breast cancer cells.
Testosterone effects on the breast: implications for testosterone therapy for women.
TLDR
Exogenous testosterone may serve as a natural endogenous protector of the breast and limit mitogenic and cancer-promoting effects of estrogen on mammary epithelium, and inclusion of testosterone in postmenopausal estrogen-progestin regimens has the potential to ameliorate the stimulating effects of combined estrogen- Progestin on the breast.
Androgen receptor mediated growth control of breast cancer and endometrial cancer modulated by antiandrogen- and androgen-like steroids
TLDR
Some steroid metabolites with distinct estrogenic properties like androst-5-ene-3 beta,17 beta-diol possess androgenic properties in this model system.
Combined estrogen and testosterone use and risk of breast cancer in postmenopausal women.
TLDR
Consistent with the elevation in risk for endogenous testosterone levels, women using estrogen and testosterone therapies have a significantly increased risk of invasive breast cancer.
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