Androgens and body fat distribution

@article{Blouin2008AndrogensAB,
  title={Androgens and body fat distribution},
  author={Karine Blouin and Ariane Boivin and Andr{\'e} Tchernof},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  year={2008},
  volume={108},
  pages={272-280}
}

Sex Differences in Body Fat Distribution

A relatively high adipose tissue glucocorticoid reactivation by 11β-hydroxysteroid dehydrogenase type 1 appears to promote specific accumulation of visceral fat and to alter adipocyte function in humans.

The impact of insulin resistance, gender, genes, glucocorticoids and ethnicity on body fat distribution

All the factors that are thought to influence body fat distribution are discussed and the possible role of insulin resistance in this process is described.

Sex Differences in Energy Balance, Body Composition, and Body Fat Distribution

Specific characteristics of each fat depot including fat cell size and metabolism, storage capacity, adipokine secretion, and, more generally, gene expression can help delineate some of the plausible links between excess visceral fat accumulation and metabolic disorders eventually leading to type 2 diabetes and cardiovascular disease.

Functional Variation in the Androgen-Receptor Gene Is Associated With Visceral Adiposity and Blood Pressure in Male Adolescents

In adolescent boys, low CAG-repeat numbers in AR may be a genetic risk factor for intra-abdominal obesity and hypertension; sympathoactivation may be an underlying link between the 2 conditions.

Androgens and obesity

Favourable changes in total body fat and regional fat distribution suggest a potential role for testosterone in obesity, however, lifestyle advice to achieve sustained weight loss should be the mainstay of management.

Circulating 5α-dihydrotestosterone, abdominal obesity and adipocyte characteristics in women

Abdominally obese women with large, metabolically active omental adipocytes appear to be characterized by reduced endogenous levels of DHT, and the assumption that high androgen levels are associated with an android body fat distribution pattern in women should be critically re-examined.

Increase in android fat mass with age in healthy women with normal body mass index.

Fat Storage in Women: From Puberty to the Menopause

Oestrogen reduces fatty acid oxidation leading to an increase in body fat which may account for the greater fat mass observed in women compared with men, and the fat gain in early pregnancy.

The Relationship between Endogenous Androgens and Body Fat Distribution in Early and Late Postmenopausal Women

Serum T levels do not correlate directly with body fat distribution, the FT in early postmenopausal women and DHEA-S levels in late post menopause women correlate positively with abdominal fat accumulation.
...

References

SHOWING 1-10 OF 104 REFERENCES

Exogenous androgens influence body composition and regional body fat distribution in obese postmenopausal women--a clinical research center study.

It is concluded that administration of exogenous androgens modulates body composition in obese postmenopausal women and independently affects visceral and sc abdominal fat.

Sex steroid hormones, sex hormone-binding globulin, and obesity in men and women.

  • A. TchernofJ. Després
  • Medicine, Biology
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
  • 2000
Sex steroid hormones in both males and females have been closely related to the regulation of adiposity, either through direct or indirect physiological mechanisms. Evidence also suggests a direct

Long-term testosterone administration increases visceral fat in female to male transsexuals.

It is concluded that long term testosterone administration in young, nonobese, female subjects increases the amount of visceral fat, and an increase in weight in this hyperandrogenic state leads to a preferential storage of fat in the visceral depot.

Effect of testosterone on abdominal adipose tissue in men.

Administration of testosterone in moderate doses to middle-aged men lead to adaptations of the metabolism of adipose tissue expected to be followed by a diminution of this mass, preliminary results suggest.

Body fat topography in women with androgen excess.

Plasma testosterone was directly correlated with the waist:hips girth ratio and this relationship was independent of obesity level, supporting the hypothesis that plasma androgens are an important determinant of body fat topography in premenopausal women.

Testosterone and regional fat distribution.

  • P. Mårin
  • Medicine, Biology
    Obesity research
  • 1995
It is suggested that T substitution to a selected group of men results in general metabolic and circulatory improvements and the prostate area needs further careful attention.

Relationship between sex hormones, body composition and metabolic risk parameters in premenopausal women.

Findings in premenopausal women indicate that the connection between sex hormones and metabolic risk factors might be indirect, probably operating through alterations in the amount of adipose tissue in the abdominal region.

Sex hormone-binding globulin levels in middle-aged premenopausal women. Associations with visceral obesity and metabolic profile.

The results suggest that the previously reported relationship between low SHBG levels and increased metabolic disease risk in women is mediated, to a large extent, by concomitant variation in body fatness and intra-abdominal adipose tissue accumulation.

Waist circumference and abdominal adipose tissue distribution: influence of age and sex.

There are significant sex differences in TAAT, VAT, and ASAT for a given WC, and the relation between WC and VAT is substantially influenced by age.
...