Androgens and androgen receptor: Above and beyond

@article{Gibson2018AndrogensAA,
  title={Androgens and androgen receptor: Above and beyond},
  author={D. Gibson and P. Saunders and I. McEwan},
  journal={Molecular and Cellular Endocrinology},
  year={2018},
  volume={465},
  pages={1-3}
}

Topics from this paper

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References

SHOWING 1-10 OF 13 REFERENCES
Androgens and androgen receptor action in skin and hair follicles
TLDR
The molecular pathophysiology of type 2 5α-reductase, AR coactivators, the paracrine factors deregulated in dermal papillae and the crosstalk between AR and Wnt signaling are reviewed in order to shed some light on new promising treatments. Expand
Androgens and endometrium: New insights and new targets
TLDR
Recent evidence is highlighted that endometrial androgen biosynthesis and intracrine action is important in preparation of a tissue microenvironment that can support implantation and establishment of pregnancy. Expand
Development of selective androgen receptor modulators (SARMs)
TLDR
This review provides insight into the evolution of SARMs from proof-of-concept agents to the cusp of therapeutic use in less than two decades, while covering contemporary views of their mechanisms of action and therapeutic benefits. Expand
From gene to therapy in spinal and bulbar muscular atrophy: Are we there yet?
TLDR
The molecular, biochemical, and cellular mechanisms underlying the pathogenesis of SBMA are reviewed and recent advances on therapeutic approaches and opportunities for this yet incurable disease are discussed, ranging from androgen deprivation, to gene silencing, to an expanding repertoire of peripheral targets, including muscle. Expand
Intracrine androgen biosynthesis, metabolism and action revisited
TLDR
An overview of human C19 steroid biosynthesis including the production of 11-oxygenated androgens, their transport in circulation and uptake into peripheral tissues, and the mechanisms of intracrinology are conceptualised and reviewed. Expand
Role of androgens in the ovary
TLDR
Findings from clinical, animal, pharmacological and novel genetic AR mouse models are summarized to provide an understanding of the important roles androgens play in the ovary, as well as providing insights into the human implications of these roles. Expand
Role of the androgen receptor in the central nervous system
TLDR
This review focuses on the implication of the neural androgen receptor in androgen-sensitive functions and behaviors, ranging from regulation of the hypothalamic-pituitary-gonadal axis and reproductive behaviors to modulation of cognition, anxiety and other non-reproductive functions. Expand
Role of the androgen receptor in urothelial cancer
TLDR
Clinical application of various anti-AR therapies available for AR-dependent prostate cancer to urothelial cancer patients is anticipated and available data suggesting the involvement of androgens and the AR pathway in the development and progression of uroclinical cancer is discussed. Expand
Sex steroids and the kidney: role in renal calcium and phosphate handling
TLDR
The presence of androgen receptors (AR) and estrogen receptors (ER) in both human and rodent kidney, although their exact localization within the kidney remains debated, supports direct effects of sex steroids in calcium and phosphate handling in the kidney. Expand
The impact of androgen actions in neurons on metabolic health and disease
TLDR
The effects of testosterone actions in the central nervous system on metabolic function in males and females are reviewed and changes within the hypothalamus that control glucose and energy homeostasis are highlighted. Expand
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