Androgens and Therapeutic Aspects of Antiandrogens in Women

@article{DiamantiKandarakis1995AndrogensAT,
  title={Androgens and Therapeutic Aspects of Antiandrogens in Women},
  author={Evanthia Diamanti-Kandarakis and George Tolis and Antoni J Duleba},
  journal={Journal of the Society for Gynecologic Investigation},
  year={1995},
  volume={2},
  pages={577 - 592}
}
Objectives: We reviewed the mechanism of androgen actions and the established and experimental uses of antiandrogens in women. Methods: Relevant studies were identified through a computerized bibliographic search (MEDLINE) and through manual review of bibliographies in relevant publications. Results: Androgens exert major effects on the functions of gonals, sex organs, and various “monreproductive” organs and systems, including muscles, liver, skin, nervous system, and the immune system, Most… Expand
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References

SHOWING 1-10 OF 286 REFERENCES
Androgen antagonists in androgen target tissues.
TLDR
Antiandrogens have been demonstrated to be beneficial in treating 5 clinical syndromes or diseases: acne, seborrhea, hirsutism with or without menstrual abnormalities; precocious puberty; benign prostatic hypertrophy; cancer of the prostate; and sexual deviates. Expand
Clinical applications of antiandrogens.
  • M. Namer
  • Medicine
  • Journal of steroid biochemistry
  • 1988
TLDR
Antiandrogens have been successfully used to treat breast cancer in men, early puberty, hypersexuality and sexual deviations, and the exact mechanism of their action requires further investigation. Expand
Pharmacological basis for clinical use of antiandrogens.
  • F. Neumann
  • Biology, Medicine
  • Journal of steroid biochemistry
  • 1983
TLDR
CPA is also a highly effective progestrogen and it inhibits gonadotrophine secretion and the progestational partial effect is especially important for the use of this drug in women in the treatment of certain dermatological disorders. Expand
Pharmacology of antiandrogens.
TLDR
Based on pharmacological and biochemical backgrounds cyproterone acetate is used in the following indications: Androgen mediated disorders of the skin such as acne, seborrhoea, hirsutism, alopecia, advanced prostatic carcinoma, precocious puberty and male hypersexuality. Expand
Steroid inhibitors of androgen-potentiated actions on skin.
TLDR
In castrated rats treated with testosterone, 3 micrograms/day oestradiol produced a greater decrease in sebum secretion than a dose of cyproterone acetate over 1000 times larger; moreover the antiandrogen reduced the incidence of sebaceous mitoses whereas the oestrogens did not. Expand
[Long-term studies with an anti-androgen/estrogen combination preparation of its effectiveness, liver tolerance and lipid metabolism in females].
The usefulness of antiandrogenic therapy with cyproterone acetate for androgenisation signs and symptoms in women, when tumours are definitely not the cause, has now been confirmed world-wide inExpand
Androgen conjugates: physiology and clinical significance.
TLDR
Serum levels of testosterone, androstenedione, and dehydroepiandrosterone sulfate (DHEAS) have been used as markers of overproduction of androgens or their precursors and are often elevated in hirsute women, but it has been more difficult to find markers of skin sensitivity to androgens. Expand
Hormonal changes induced by the pure antiandrogen flutamide in postmenopausal women with advanced breast cancer.
TLDR
Hormonal changes induced by the pure antiandrogen flutamide were studied in three postmenopausal metastatic breast cancer patients and suggest two possible mechanisms by which the drug exerts itsAntiandrogenic activity: inhibition of conversion of testosterone into the more active DHT, and inhibition of synthesis of the adrenal precursors of active androgens. Expand
Antiandrogenic effect of spirolactones: mechanism of action.
TLDR
It seems likely that spirolactones, besides their action on testosterone biosynthesis, exert their antiandrogenic activity via a peripheral androgen antagonism. Expand
The Effects of Sex Hormones on the Immune System in Pregnancy
  • R. Lahita
  • Biology, Medicine
  • American journal of reproductive immunology
  • 1992
TLDR
The role of the catechol estrogens is discussed, and oxidation of testosterone to weak androgens is found in women with systemic lupus erythematosus (SLE). Expand
...
1
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3
4
5
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