Androgens and Dry Eye in Sjögren's Syndrome a
@article{Sullivan1999AndrogensAD, title={Androgens and Dry Eye in Sj{\"o}gren's Syndrome a}, author={David A. Sullivan and L. Alexandra Wickham and EDUARDO M. Rocha and Kathleen L. Krenzer and Benjamin D. Sullivan and Rebecca J. Steagall and Jennifer Marie Cermak and Mohamad R. Dana and M. David Ullman and {\'E}lcio Hideo Sato and JIANPING GAO and Flavio Jaime da Rocha and Masafumi Ono and LILIA A. Silveira and Ross William Lambert and Robert Kelleher and Dorothy Bazzinotti Tolls and Ikuko Toda}, journal={Annals of the New York Academy of Sciences}, year={1999}, volume={876} }
ABSTRACT: Sjögren's syndrome is an extremely complex and currently incurable autoimmune disorder, which occurs primarily in females, and is associated with lacrimal gland inflammation, meibomian gland dysfunction, and severe dry eye. We hypothesize that androgen deficiency, which reportedly occurs in primary and secondary Sjögren's syndrome (e.g., systemic lupus erythematosus, rheumatoid arthritis), is a critical etiologic factor in the pathogenesis of dry eye syndromes. We further hypothesize…
136 Citations
Sjögren’s syndrome: An old tale with a new twist
- Medicine, BiologyArchivum Immunologiae et Therapiae Experimentalis
- 2009
This review focuses on the use of mouse models, how genetic predisposition plays a role in the natural history of the disease, as well as a presentation of new findings pertaining to the role of TH1, TH2, and TH17 cells in the pathogenesis of SjS.
Androgen influence on lymphocyte gene expression.
- Medicine, BiologyAdvances in experimental medicine and biology
- 2002
It is discovered that androgen administration to the female MRL/Mp-lpr/ lpr (MRL/lpr) and NZB/NZW F1 mouse models of Sjogren’s syndrome causes a dramatic suppression of the inflammation in, and a significant increase in the functional activity of, lacrimal glands.
Autoimmune Epithelitis and Chronic Inflammation in Sjögren’s Syndrome-Related Dry Eye Disease
- MedicineInternational journal of molecular sciences
- 2021
This review highlights autoimmune epithelitis of the ocular surface, chronic inflammation, and several other molecules in the tear film, cornea, conjunctiva, lacrimal glands, and meibomian glands that represent potential targets in the treatment of SS-related dry eye disease.
Unraveling the pathophysiology of Sjogren syndrome-associated dry eye disease.
- Medicine, BiologyThe ocular surface
- 2009
Sjogren’s syndrome: evolving therapies
- MedicineExpert opinion on investigational drugs
- 2003
The high placebo response (probably reflecting the beneficial response of mechanical stimulation of the buccal mucosa by the lozenge) and the response to much cheaper therapies (such as acid maltose lozenges) may offer safer and cheaper alternatives.
Therapeutic effect of cevimeline on dry eye in patients with Sjögren's syndrome: a randomized, double-blind clinical study.
- MedicineAmerican journal of ophthalmology
- 2004
Sjögren’s Syndrome
- Medicine
- 2002
Signs and symptoms attributable to infiltration and destruction of lacrimal and salivary glands by inflammatory cells, resulting in ocular and oral dryness and systemic symptoms including fatigue are now also recognized to be significant features of SS.
A Scleroderma Patient Complaining of Dry and Gritty Sensation of the Eyes
- Medicine
- 2011
The aim of management of dry eyes is to provide symptomatic relief, reduce ocular surface inflammation, and prevent complications.
Effect of androgen deficiency on the human meibomian gland and ocular surface.
- MedicineThe Journal of clinical endocrinology and metabolism
- 2000
The results demonstrate that patients taking antiandrogen treatment had a significant increase in the frequency of appearance of tear film debris, an abnormal tear film meniscus, irregular posterior lid margins, conjunctival tarsal injection, and orifice metaplasia of the meibomian glands.
New concepts in the pathogenesis of Sjögren syndrome: many questions, fewer answers
- Medicine, BiologyCurrent opinion in rheumatology
- 2003
Evidence confirms that lymphocytic disturbances, including ectopic germinal center formation and aberrations of cellular signaling play a significant role in Sjögren syndrome and indicates the central role of derangement of lymphocyte regulation in this disease.
References
SHOWING 1-10 OF 79 REFERENCES
Androgen stimulation of lacrimal gland function in mouse models of Sjögren's syndrome
- Biology, MedicineThe Journal of Steroid Biochemistry and Molecular Biology
- 1997
Does androgen insufficiency cause lacrimal gland inflammation and aqueous tear deficiency?
- Medicine, BiologyInvestigative ophthalmology & visual science
- 1999
It is shown that androgen treatment suppresses inflammation and stimulates the function of lacrimal glands in mouse models of Sjögren's syndrome, and androgen insufficiency alone does not cause Lacrimal gland inflammation, a SJögren’s syndrome-like pathology in lacrima tissue, or aqueous tear deficiency in nonautoimmune animals and humans.
Sjögren's syndrome: immunologic and neuroendocrine mechanisms.
- MedicineAdvances in experimental medicine and biology
- 1994
Future understanding of the mechanisms of destruction of the salivary and lacrimal glands may provide a more rationale approach to therapy and help to understand the environmental factors that precipitate SS.
Impact of gender on exocrine gland inflammation in mouse models of Sjögren's syndrome.
- Biology, MedicineExperimental eye research
- 1999
It is demonstrated that gender-, strain- and tissue-related differences exist in the extent of inflammation in several mouse models of Sjögren's syndrome, and no gender-related variations were present in the degree of inflammation.
Effect of androgen deficiency on the human meibomian gland and ocular surface.
- MedicineThe Journal of clinical endocrinology and metabolism
- 2000
The results demonstrate that patients taking antiandrogen treatment had a significant increase in the frequency of appearance of tear film debris, an abnormal tear film meniscus, irregular posterior lid margins, conjunctival tarsal injection, and orifice metaplasia of the meibomian glands.
Pathogenesis and treatment of Sjögren's syndrome.
- Medicine, BiologyCurrent opinion in rheumatology
- 1997
Critical features of pathogenesis in Sjögren's syndrome include: failure to "delete" autoimmune T cells at the level of thymic selection; "homing" of autoimmune lymphocytes to salivary and lacrimal glands via high endothelial venules; clonal expansion of autoimmune T Cells in the glands; and failure to remove autoimmune Tcells by normal mechanisms of apoptosis.
Sjögren's syndrome: autoimmune epithelitis.
- MedicineBailliere's best practice & research. Clinical rheumatology
- 2000
Based on the sequential application of the validated European classification criteria for SS, a practical algorithm for diagnosis is presented and progress in the understanding of the broad clinicopathological spectrum of the entity remains largely empirical and symptomatic.
Testosterone-induced suppression of autoimmune disease in lacrimal tissue of a mouse model (NZB/NZW F1) of Sjögren's syndrome.
- Medicine, BiologyInvestigative ophthalmology & visual science
- 1991
It is demonstrated that androgen administration may inhibit the progression of autoimmune disease in lacrimal and submandibular glands of NZB/NZW F1 mice.
Androgen regulation of the meibomian gland.
- BiologyAdvances in experimental medicine and biology
- 1998
It is hypothesized that androgens may regulate meibomian gland function, enhance the quality and quantity of lipids produced by this tissue and stimulate the formation of the tear film’s lipid layer.