Androgens Contribute to Sex Differences in Myocardial Remodeling under Pressure Overload by a Mechanism Involving TGF-β

@inproceedings{Montalvo2012AndrogensCT,
  title={Androgens Contribute to Sex Differences in Myocardial Remodeling under Pressure Overload by a Mechanism Involving TGF-β},
  author={Cristopher Montalvo and Ana Victoria Villar and David Castillo Merino and Raquel Potter Garcia and Miguel Ares and Magdalena Adrados de Llano and M. Teresa Carrillo Cobo and Mar{\'i}a A Hurl{\'e} and J Francisco Nistal},
  booktitle={PloS one},
  year={2012}
}
BACKGROUND In clinical studies, myocardial remodeling in aortic valve stenosis appears to be more favorable in women than in men, even after menopause. In the present study, we assessed whether circulating androgens contribute to a less favorable myocardial remodeling under pressure overload in males. We examined sex-related differences in one-year-old male and female mice. Whereas male mice at this age exhibited circulating androgen levels within the normal range for young adults, the… CONTINUE READING
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