Androgenic stimulation of progesterone production by granulosa cells from preantral ovarian follicles: further in vitro studies using replicate cell cultures.


The influence of testosterone (T) on progesterone (P) production by isolated rat ovarian granulosa cells was studied in vitro using a new replicate culture technique. Preantral granulosa cells from ovaries of estrogen-primed hypophysectomized immature female rats were cultured in the presence of graded concentrations of T, diethylstilbestrol (DES… (More)